Mass Spectrometric Methods Development

In 1998 Matthias Mann took up a professorship in Odense, Denmark and Matthias Wilm became group leader at the EMBL. Being an instrumentation group we continued to develop methods to improve protein characterization by mass spectrometry.

Method development:

  • Noise filtering technique to improve peptide detection

  • Data processing to improve automated peptide identification

  • Differential scanning to improve de-novo sequencing

  • Parallel fragmentation of peptides to improve specific detection of secondary modifications